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Cell treatment helps mice long after spine injury

Posted by JLo
Tuesday, August 24, 2010

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In this study, Aileen Anderson and colleagues used spinal cord injured NOD-scid mice to test the ability of transplanted human neural stem cells (hCNS-SCns) to "survive, differentiate, migrate, and promote improved locomotor recovery." Because NOD-scids lack a functioning immune system, the hCNS-SCns were not be rejected. The mice were transplanted at thirty days post injury, which the study authors define as "early chronic" injury - meaning that the spinal cord environment has become fairly stable and is no longer dynamically changing as it does in the acute and subacute stages immediately following injury. The preliminary findings are encouraging, suggesting that early chronic injury might well be amenable to hCNS-SCn transplantation to improve recovery without evidence of any transplant-related pain.

Dr. Anderson is Scientific Director of the Reeve Foundation's Animal Core Laboratory at UC Irvine and the Foundation provided partial underwriting for this research.

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Categories: Research

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